General Cell Lines and Cell Cultures
ATCC TRAMP-C2; Prostate Adenocarcinoma; Mouse (Mus musculus)
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ATCC Synthetic Sapovirus; RNA
Quantitative synthetic RNA for Sapovirus can be used for assay development, verification, and validation as well as monitoring of day-to-day test variation and lot-to-lot performance of molecular-based assays. The quantitative format allows for the generation of a standard curve for quantitative PCR (qPCR) to determine viral load. This preparation includes fragments from the RNA-dependent RNA polymerase, VP1, and polyprotein regions.
ATCC LS 180; Colorectal Carcinoma; Human (Homo sapiens)
LS 180 is a cell exhibiting epithelial morphology isolated from the colon of a White, 58-year-old female patient with colorectal. This cell line was deposited by Northwestern University.
Abcam SKF 97541, Highly GABAB agonist, 10MG
MW 137.12 Da, Purity >98%. Highly potent GABAB agonist, 10-fold more potent than Baclofen (ab120149). (EC50 values for depression of striatal synaptic potentials are 920 nM and 1.25 μM for SKF97541 and baclofen, respectively). Also available in simple stock solutions (ab146688) - add 1 ml of water to get an exact, ready-to-use concentration.
The product is subject to the following: Abcam Restricted Use Statement
Eurofins Discoverx ChemiScreen NOP/ORL1 Opioid Receptor Stable Cell Line, 2 vials. (HTS040C)
The ChemiScreen NOP/ORL1 Opioid Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. orphanin FQ) based activation of OPRL1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses OPRL1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of OPRL1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiScreen PK1 Prokineticin Receptor Stable Cell Line, 2 vials. (HTS074C)
The ChemiScreen PK1 Prokineticin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prokinectin, EG-VEGF) based activation of PROKR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PROKR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of PROKR1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiBrite FFA1/GPR40 Free Fatty Acid Receptor Stable Cell Line, 2 vials. (HTS038L)
The ChemiBrite FFA1/GPR40 Free Fatty Acid Receptor cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. free fatty acids) based activation of FFAR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses FFAR1, a naturally Gq coupled GPCR. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of FFAR1, the resulting calcium activity can be assayed in either detection mode. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx Ready-to-Assay V2 Vasopressin Receptor Frozen Cells, 2 Vials of Cells. (HTS060RTA)
The Ready-to-Assay V2 Vasopressin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. vasopressin) based activation of AVPR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses AVPR2 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of AVPR2, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen FFA2/GPR43 Free Fatty Acid Receptor Stable Cell Line, 2 vials. (HTS063C)
The ChemiScreen FFA2/GPR43 Free Fatty Acid Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. free fatty acids) based activation of FFAR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses FFAR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of FFAR2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx Ready-to-Assay β3 Adrenergic Receptor Frozen Cells, 2 Vials of Cells. (HTS159RTA)
The Ready-to-Assay β3 Adrenergic Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. epinephrine and norepinephrine) based activation of ADRB3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses ADRB3 alongside exogenous levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of ADRB3, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
ATCC Neisseria meningitidis; MC58; genomic DNA
Genomic DNA isolated from Neisseria meningitidis strain. MC58. This bacterial strain is also available as ATCC Catalog No.: BAA-355D-5™.
ATCC Streptococcus pyogenes
Streptococcus pyogenes strain QC A62 is a whole-genome sequenced bacterium that was isolated from a human throat culture. This culture is typed as Lancefield’s group A and it can be used in emerging infectious disease research and as a quality control strain for BBL products.
ATCC Quantitative Synthetic; Human coronavirus; Strain NL63 RNA
Quantitative synthetic Human coronavirus NL63 RNA can be used for assay development, verification, and validation as well as monitoring of day-to-day test variation and lot-to-lot performance of molecular-based assays. The quantitative format allows for the generation of a standard curve for quantitative PCR (qPCR) to determine viral load. This preparation includes fragments from NSP3 (ORF 1A), Rdrp (nsp12), NTPase (nsp13), nsp16, spike protein, nucleocapsid, and 3’ untranslated regions.